Ngā Tangata Pūtaiao Tino Pai o te Taiao:

Kua whakaingoatia a Yunlong Cao o Te Whare Wānanga o Peking mō ngā rangahau hou mō te mate urutā coronavirus

I te 15 o Hakihea 2022, i pānuitia e Nature tana Nature's 10, he rārangi o ngā tāngata tekau kua whai wāhi ki ngā huihuinga pūtaiao nui o te tau, ā, ko ā rātou kōrero e tuku ana i tētahi tirohanga ahurei mō ētahi o ngā huihuinga pūtaiao tino nui o tēnei tau whakamiharo.

I roto i tētahi tau o ngā raruraru me ngā kitenga whakahihiri, i whiriwhiria e Nature te tekau tāngata mai i ngā tohunga whetū kua āwhina i a tātou ki te mārama ki te oranga tawhiti rawa atu o te ao, ki ngā kairangahau kua whai wāhi nui ki ngā mate urutā o te Karauna Hou me te mate rewharewha makimaki, ki ngā taote pokanga kua takahi i ngā rohe o te whakawhitinga okana, e ai ki a Rich Monastersky, te ētita matua o Nature Features.

Nō te Biomedical Frontier Innovation Center (BIOPIC) i Te Whare Wānanga o Peking a Yunlong Cao. I puta a Tākuta Cao i Te Whare Wānanga o Zhejiang me te tohu Paetahi i roto i te Ahupūngao, ā, i whiwhi ia i tana PhD mai i te Tari Matū me te Koiora Matū o Te Whare Wānanga o Harvard i raro i a Xiaoliang Xie, ā, he Kairangahau Hoa ia i tēnei wā i te Biomedical Frontier Innovation Center i Te Whare Wānanga o Peking. Kei te arotahi a Yunlong Cao ki te whakawhanake i ngā hangarau raupapatanga pūtau-kotahi, ā, kua āwhina tana rangahau ki te whai i te whanaketanga o ngā coronavirus hou me te matapae i ētahi o ngā whakarerekētanga e arahi ana ki te hanganga o ngā momo whakarerekētanga hou.

I te 18 o Mei 2020, i whakaputa a Xiaoliang Xie/Yunlong Cao me ētahi atu i tētahi tuhinga i roto i te puka Cell, ko tōna taitara: "Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of recovery patients' B cells" Te pepa rangahau.

E whakaatu ana tēnei rangahau i ngā hua o tētahi matawai paturopi whakakore mate korona hou (SARS-CoV-2), i whakamahi i tētahi tūāpapa raupapatanga RNA pūtau-kotahi me te VDJ tere-whakaputa hei tautuhi i ngā paturopi monoclonal whakakore kaha e 14 mai i te neke atu i te 8500 paturopi IgG1 e herea ana ki te antigen i roto i te 60 tūroro COVID-19 kua ora.

E whakaatu ana tēnei rangahau mō te wā tuatahi ka taea te whakamahi tika i te raupapatanga pūtau-kotahi tere-whakaputa mō te kimi rongoā, ā, he painga tōna he tukanga tere, whai hua hoki, e oati ana ka huri i te huarahi e tirotirohia ai e te tangata ngā paturopi whakakore i ngā huaketo pangia.

I te 17 o Hune 2022, i whakaputa a Xiaoliang Xie/Yunlong Cao me ētahi atu i tētahi pepa ko te taitara: BA.2.12.1, BA.4 me BA.5 escape antibodies e elicited by Omicron infection i roto i te puka Nature.

I kitea i tēnei rangahau ko ngā momo hou o ngā momo ira Omicron BA.2.12.1, BA.4 me BA.5 i whakaatu i te pikinga o te mawhitinga ārai mate me te whakakorenga nui o te mawhitinga plasma i roto i ngā tūroro i pangia e Omicron BA.1 kua ora.

E whakaatu ana ēnei kitenga kāore pea te kano kano Omicron e ahu mai ana i te BA.1 e pai ana hei whakakaha i roto i te horopaki werohanga o nāianei, ā, kāore ngā paturopi i puta mai e whakarato i te parenga whānui ki te momo ira whakarerekē hou. Hei tāpiri, he tino uaua ki te whakatutuki i te ārai mate kahui mā te mate Omicron nā te āhuatanga 'immunogenic' o ngā coronavirus hou me te tere o te whanaketanga o ngā wāhi ira whakarerekētanga mawhiti ārai mate.

I te 30 o Oketopa 2022, i whakaputa te tīma a Xiaoliang Xie/Yunlong Cao i tētahi pepa rangahau ko te taitara: Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution in the preprint bioRxiv.

E kī ana tēnei rangahau ko te painga o te XBB ki te BQ.1, tera pea nā ngā panoni i waho o te rohe herenga kaiwhakawhiwhi (RBD) o te spinosin, kei te XBB anō hoki ngā whakarerekētanga ira i roto i ngā wāhanga o te ira e whakamārama ana i te rohe hanganga N-terminal (NTD) o te spinosin, ā, ka taea e te XBB te mawhiti i ngā paturopi whakakore i te NTD, ka taea ai e ia te pangia te hunga he ārai mate ki te BQ.1 me ngā momo e pā ana. Heoi, he mea tika kia mōhiotia kei te puta ngā whakarerekētanga ira i te rohe NTD i roto i te BQ.1 i te tere tino tere. Ka tino whakarei ake ēnei whakarerekētanga i te kaha o ēnei momo ki te mawhiti i ngā paturopi whakakore i hangaia e te werohanga me ngā mate o mua.

I mea a Tākuta Yunlong Cao, tera pea he parenga ki te XBB mēnā ka pangia e te BQ.1, engari me nui ake ngā rangahau hei whakarato taunakitanga mō tēnei.

Haunga a Yunlong Cao, tokorua atu anō i uru ki te rārangi mō ā rāua takoha nui ki ngā take hauora tūmatanui o te ao, ko Lisa McCorkell rāua ko Dimie Ogoina.

He kairangahau a Lisa McCorkell nō Long COVID, ā, hei mema whakatū o te Patient-Led Research Collaborative, kua āwhina ia ki te whakapiki i te mōhiotanga me te putea mō ngā rangahau mō te mate.

He rata mate pipiri a Dimie Ogoina i te Whare Wānanga o Niger Delta i Nigeria, ā, nā āna mahi mō te mate urutā makimaki i Nigeria i whakarato ngā mōhiotanga matua mō te pakanga ki te mate urutā makimaki.

I te 10 o Hānuere 2022, i pānuitia e te Kura Hauora o Te Whare Wānanga o Maryland te whakaurunga ngākau poaka tuatahi o te ao kua whakatikatikaina ira ki roto i te tangata ora, i te wā i whiwhi ai a David Bennett, he tūroro ngākau 57-tau te pakeke, i tētahi whakawhitinga ngākau poaka kua whakatikatikaina ira hei whakaora i tōna ora.

Ahakoa e rua noa ngā marama i roa ake ai te oranga o David Bennett i tēnei ngākau poaka, he angitu nui, he putanga nui hoki i roto i te ao o te whakawhiti ira tangata. Ko Muhammad Mohiuddin, te taote pokanga i ārahi i te tīma i whakaoti i tēnei whakawhitinga tangata o te ngākau poaka i whakatikatikaina ira, i whakaingoatia ki te rārangi o ngā Tāngata Pai 10 o te Tau a Nature.

He maha atu anō i whiriwhiria mō te whakatairanga i ngā whakatutukitanga pūtaiao whakamiharo me ngā whanaketanga kaupapa here nui, tae atu ki te tohunga whetū a Jane Rigby o te Goddard Space Center o NASA, he tūranga nui tāna i roto i te kaupapa a te Webb Space Telescope kia taea ai te kawe i te karu whetū ki te wāhi me te mahi tika, me te kawe i te kaha o te tangata ki te tūhura i te ao whānui ki tētahi taumata hou, teitei ake. Ko Alondra Nelson, hei Kaiwhakahaere Tūturu Kaupapa Here Pūtaiao me te Hangarau o te Tari Pūtaiao me te Hangarau o Amerika, i āwhina i te whakahaere a te Perehitini Biden ki te whakawhanake i ngā wāhanga nui o tana kaupapa pūtaiao, tae atu ki tētahi kaupapa here mō te pono o te pūtaiao me ngā aratohu hou mō te pūtaiao tuwhera. Ko Diana Greene Foster, he kairangahau whakatahe me te tohunga taupori i Te Whare Wānanga o California, San Francisco, i whakarato i ngā raraunga matua mō te pānga e tumanakohia ana o te whakataunga a te Kōti Matua o Amerika ki te whakakore i ngā tiakitanga ture mō ngā tika whakatahe.

Kei runga anō hoki i te rārangi tekau o runga o tēnei tau ngā ingoa e pā ana ki te whanaketanga o te huringa āhuarangi me ētahi atu raruraru o te ao. Ko rātou ēnei: ​​António Guterres, Hekeretari-Tianara o te Kotahitanga o ngā Whenua o te Ao, Saleemul Huq, Kaiwhakahaere o te International Centre for Climate Change and Development i Dhaka, Bangladesh, me Svitlana Krakovska, Tumuaki o te tira o Ukraine ki te UN Intergovernmental Panel on Climate Change (IPCC).